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Health effects in biomedical research laboratory personnel in Sweden : cancer occurrence and reproductive outcomes
(2000-03-14)
. The OR for 'Large for gestational age' (LGA) infants in association with the mother's laboratory work was 1.9 (CI 0.7-5.2) and for male infants in connection to mother's work with radioactive isotopes, 3.4 (CI 0.8-14.2). The number of malformations was low...
Nuclear hormone receptors studied by molecular dynamics computer simulations
(2004-03-05)
Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. The ...
Conflict resolution and development of communication competence in preschool boys with language impairment
(2005-11-25)
Children with Language Impairment (LI) have difficulties navigating peer situations, withdraw from social interaction and are at risk for developing further behavioral and socio-emotional problems. Children with LI often ...
Assisted reproduction technology in men with ejaculatory dysfunction with special reference to spinal cord injury
(1998-05-16)
Background: Men afflicted by spinal cord injury (SCI), myelomeningocele (MMC) and testicular cancer (TC) with retroperitoneal lymph-node dissection (RPLND) share the problem of infertility due mainly, but not exclusively, ...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ...
The role of autophagy in anticancer therapy
(2018-08-24)
Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject ...
Roles of Myc and Mad in cell cycle and apoptosis
(2006-05-12)
The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization ...
Effects of DNA damage and vesicular exchange in P. falciparum
(2019-05-28)
Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
Nucleic acid in gene delivery and gene regulation
(2011-08-01)
The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic ...
Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
(2022-12-13)
Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and ...