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Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?
(2000-04-06)
were for the first time identified in detail within the sequences amino acids (aa) 67-86 (peptide T7-13) and 798-806 (peptide gB51) of gB. Using optimised coating conditions for enzyme-linked immunosorbent assay (ELISA) the peptides T7-13 and gB51...
Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids
(2010-01-08)
treated with cholestyramine or chenodeoxycholic acid (CDCA). Following stimulation of bile acid synthesis with cholestyramine the mRNA levels for HNF4alpha were upregulated and positively correlated to the expression levels of CYP7A1, the rate limiting...
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(2022-04-13)
function (CIF), at two-years was more frequent for SBP than EMP (35% compared to 7%). However, relative survival was not better for EMP than for SBP. Patients in the study with primary PCL had a poor prognosis with no patients being alive 5 years after...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular ...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
Chronic complications of diabetes represent a major medical and economical concern. It is an imperative need to establish the pathogenic mechanisms that contribute to development of chronic complications in order to design ...
Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina
(2020-11-09)
Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying ...
Regulation of the vertebrate transcriptome in development and disease
(2016-01-15)
In the last decade we have seen a tremendous development in the omics area (genomics,
transcriptomics, proteomics etc.), making high throughput methods increasingly costeffective and available. The development in ...
Regulation of cellular responses to hypoxia by HIF-1alpha-dependent and -independent signaling pathways
(2012-08-13)
Hypoxia is a state of inadequate oxygen supply to the cells and tissues of the body. It plays a critical role in embryonic development, as well as in various physiological and pathological processes. Hypoxia-inducible ...
Oxygen-dependent regulation of HIF-1alpha expression and function
(2009-09-04)
Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are ...