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Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?
(2000-04-06)
Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a ...
Therapist-guided internet treatment for alcohol use disorders
(2017-11-08)
Background: Alcohol Use Disorders (AUD) are among the most common psychiatric disorders but the vast majority never receive treatment. Internet interventions have the potential to reach some of those who currently do not ...
Myocardial gene therapy and gene expression in angina pectoris
(2006-03-31)
Background: Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, ...
Mediators of synaptic activity in anxiety- and depression-related behaviors
(2012-05-16)
Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously ...
Studies on the role of HIF-1 in the control of infection with Mycobacterium tuberculosis
(2022-12-21)
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), is responsible for most deaths caused by a bacterium globally. Two main reasons for this are that (Bacille Calmette–Guérin) BCG, the ...
Decoding the contribution of transcription factors to cell fate determination
(2018-11-19)
It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given ...
Resident T cells steer tissue responses in human skin
(2023-01-04)
The human skin constitutes a biological barrier against threats to the body from the surrounding environment. Tissue-resident memory cells (TRM) reside in the skin and provide local memory of previous encounters with ...
Human cytotoxic lymphocyte differentiation in health and disease
(2017-10-26)
Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory ...