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Immunity against porcine islet xenografts in man
(2005-11-25)
Due to the lack of organs for clinical transplantation, alternative sources have been investigated. One solution to this shortage could be xenotransplantation, i.e. the transplantation of organs/cells across species barriers. ...
Application of genetic analyses in studies of syndromic and non-syndromic cleft lip and palate
(2000-02-21)
Linkage analysis is one of the first and essential steps in the localization of human disease genes. In this study, the method was first applied in mapping of the disease in two families with isolated hyperparathyroidism ...
Organization of the spinal locomotor network in zebrafish : pattern of recruitment and origin of excitatory drive
(2012-11-21)
Locomotion is of vital importance for animals to survive in a complex environment. Locomotor movements are generated by neuronal networks that reside in the spinal cord and are composed of motoneurons and interneurons. The ...
Studies on the regulatory roles of cholesterol and bile acids
(2007-05-04)
Cholesterol is essential for normal growth and development in mammals.
However, excess cholesterol can be harmful leading to diseases such as
atherosclerosis and gallstones. Once formed the ring structure of
cholesterol ...
Cellular immunity and inflammation in atherosclerosis
(2001-11-09)
Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the ...
Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions
(2017-05-08)
A bacteria infection in the living host is the summation of a myriad of interactions. Reductionistic and sacrificial experiment models cannot replicate this complexity. The Tissue Microbiology approach overcomes this by ...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(2022-04-29)
Inorganic nanomaterials are attractive candidates for biomedicine as they can offer increased stability including light, temperature and chemical stability while also offering the benefits of high-throughput synthetic ...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
that exogenous expression of HES-1 causes cell cycle arrest in the G1 phase of the cell cycle. We found the cell cycle factor E2F-1, critical for G1 to S-phase progression, to be regulated by HES-1, via a cis-element in the 5 regulatory region of the E2F-1 gene...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal ...