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Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation
(2000-01-14)
of the translation initiation site, but no TATA or CAAT consensus sequences were found 5' of these sites.
The IGFBP-4 gene is contained within 15.3 kb, with its transcription initiation site located 28 bp downstream of a TATA box sequence and 286 bp 5...
A battle between host and pathogen : the innate immune response and enterovirus evasion strategies
(2014-09-18)
Infections with Coxsackieviruses are common and in most cases the infection is asymptomatic and efficiently cleared. On rare occasions, however, an infection can lead to severe diseases including myocarditis, hepatitis and ...
Genotype-phenotype relations in SF3B1 mutated myelodysplastic syndromes with ring sideroblasts
(2016-10-28)
in the spliceosome gene SF3B1 are found in a majority of MDS-RS cases and are associated with the ring sideroblast phenotype and a favorable prognosis. MDS-RS is a usually slowly progressing disease of the elderly distinguished by an initial phase of erythroid...
Enterovirus infections in type 1 diabetes and cystic fibrosis : antiviral defence and viral immune evasion strategies
(2017-04-20)
by which Coxsackeiviruses can cause beta cell dysfunction. We found that the viral proteins 2Apro, 3A and 3Cpro could, independently of one other, affect exocytosis with 2Apro and 3Cpro targeting calcium influx while 3A inhibited exocytosis via a calcium...
Dysregulated Notch signaling in breast cancer and liver disease
(2015-10-13)
-specific sequencing (S3). Using an intermixed human tumor and mouse stroma cell population from xenografted cells, we demonstrate a way to decode transcriptomes, separated by their species-specific differences, with 99% accuracy. This technique circumvents current...
Understanding ageing : the role of mitochondria in determination of caenorhabditis elegans life span
(2011-08-23)
Mitochondria are organelles found in eukaryotic cells. They are involved in many
vital cellular functions. Consequently, mitochondrial dysfunction leads to a variety of human disorders. Many studies of the last 50 years ...
Untangling the contribution of untranslated regions to mRNA translation in health and disease
(2022-01-19)
characterized an mRNA subset, which despite its transcriptional regulation, does not lead to altered protein levels. This phenomenon, termed translational offsetting, associated with distinct features in the 3’ untranslated region and mRNA stability...
Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease
(2020-08-14)
the extent of Notch2 and Notch3 activation. Lacrymosa: In Paper V, we observed that hyperactive Notch in the luminal lineage during lactation cause defect in ductal development and led to mammary tumour development. Furthermore, we showed that this lineage...