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Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation
(2000-01-14)
Insulin-like growth factors (IGF-I and IGF-II) are among the more abundant growth factors isolated from bone tissue and are synthesized by various bone cells including osteoblasts. The activity of IGFs is controlled by a ...
Mammalian sperm flagella and cilia
(2009-04-17)
In mammals, both sperm flagella and cilia are axoneme-containing organelles. The sperm flagella are major parts of the spermatozoa that are male gametes produced in the testis from progenitor spermatogonia through a process ...
Small-molecule inhibitors of the receptor tyrosine kinases : promising tools for targeted cancer therapies
(2014-08-11)
Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a ...
Linkage and association analysis in multiple sclerosis
(2001-09-03)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that ...
New treatment strategies for growth failure caused by chronic inflammation in children
(2012-12-21)
Chronic inflammation during childhood often leads to impaired bone growth and reduced height in adulthood. Interleukin-1β (IL-1β), interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) are pro-inflammatory cytokines ...
Breast cancer survivors : information needs, attitudes towards illness and quality of life
(2010-03-26)
Breast cancer (BC) is the most common female cancer. Only in Sweden about
7300 women are affected each year and 1500 die from the disease.
Following progress in early detection and therapy there has been a marked
improvement ...
Local regulation of growth plate chondrocytes : molecular mechanisms and implications for longutidinal growth
(2010-10-08)
The regulation of linear growth is a complex and intriguing process that has the growth plate cartilage as its final target. Growth plate is a specialized cartilage localized in the end of the long bones between the ...
Multiple sclerosis : MRI diagnosis, potential treatment and future potential for nanoparticle applications
(2005-10-10)
Multiple Sclerosis is an inflammatory demyelinating and neurodegenerative disease of the central nervous system. Magnetic resonance imaging is an important tool for diagnosing of Multiple Sclerosis and for, in vivo, ...
From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR
(2015-03-19)
Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated ...
Role of mitochondrial ribosomal protein S18-2 in cancerogenesis and in regulation of stemness and differentiation
(2017-05-02)
Mitochondria carry their own ribosomes (mitoribosomes) for the translation of mRNA encoded by mitochondrial DNA. The architecture of mitoribosomes is mainly composed of mitochondrial ribosomal proteins (MRPs), which are ...