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Oncogenic mechanisms of AIDS-related neoplasia in humans and SIV infected monkeys
(1999-11-19)
Patients with AIDS or immunosuppressive post-transplant therapy are at high risk to develop Kaposi's sarcoma (KS) and malignant lymphoma that represent clinically lethal complications. Lymphomagenesis in simian immunodeficiency ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
(2001-11-02)
The transforming growth factor beta (TGFbeta) superfamily of polypeptide
growth factors encompasses more than 30 diverse mammalian members. They
are involved in most cellular processes, ranging from cell proliferation
and ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(2022-04-29)
peroxide from bacterial cultures is described. The sensing system consists of a reference emission from Y2O3:Tb3+ which are decorated with CeO2:Eu3+ nanoparticles which provide the hydrogen peroxide sensitive emission. This system was applied...
The genetics of experimental arthritis in rodents
(2012-10-05)
Unravelling the genetic susceptibility to complex autoimmune diseases and understanding these pathologies on a mechanistic level are major obstacles to improve our possibilities for therapeutic intervention and an increase ...
Evaluation of new strategies to elicit neutralizing antibodies against HIV-1
(2008-08-22)
The development of an effective HIV-1 vaccine must be considered one of the greatest biomedical challenges of today. The nature of the virus, characterized by immense variability as well as its tropism for the essential ...
Getting going on getting better : how is systematic quality improvement established in a healthcare organization? Implications for change management theory and practice
(2007-08-31)
Despite the widespread application of quality improvement (QI), there is
enduring uncertainty about its effectiveness in healthcare as an approach
to the inevitable, but challenging, task of managing organizational
change. ...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...