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Cognitive functioning in late senescence : influences of age and health
(1999-11-12)
The overall aim of this doctoral thesis was to investigate potential age-related differences between groups of healthy very old adults from 75 to 96 years of age in various cognitive functions. An additional objective was ...
Regulation of eukaryotic cell physiology using organic bioelectronics
(2011-03-25)
The field of organic bioelectronics deals with the implementation of conducting polymer science in biology and medicine. The purpose of this thesis was to develop organic bioelectronic devices for the regulation of eukaryotic ...
Inflammation and cytokine production in experimental neuroinflammatory disorders
(2013-09-04)
Glutamate excitotoxicity is involved in the pathogenesis of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Kainic acid (KA), an analogue ...
Ready to pull : force transmission during vascular development
(2019-12-17)
The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the ...
Point-of-care testing of platelet P2Y12-inhibition in patients with acute coronary syndrome
(2018-05-08)
Background: The point-of-care platelet function test Plateletworks® has been shown to identify patients with high platelet aggregation despite P2Y12 inhibition, also known as high-on-treatment platelet reactivity (HPR), ...
Do-Not-Attempt-Cardiopulmonary-Resuscitation decisions in the hospital setting
(2021-10-01)
Background: A Do-Not-Attempt-Cardiopulmonary-Resuscitation (DNACPR) order can be placed when CPR is not in accordance with the patient’s will, when CPR is considered not to benefit the patient, or when CPR is very unlikely ...
Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models
(2016-05-20)
The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination ...
Interactions between mast cells and smooth muscle in asthma models
(2014-04-04)
Allergic asthma is the major phenotype of asthma and is characterized by specific responses to allergens as well as airway hyperresponsiveness (AHR), inflammation and remodelling. Mast cells and airway smooth muscle cells ...
Derivation, enrichment and characterization of dopaminergic neurons from pluripotent stem cells
(2010-04-06)
Parkinson s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons residing in the substantia nigra and innervating the straitum. Current medical interventions provide initial symptomatic ...
Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction
(2013-05-03)
Treatment of hospitalised patients is generally governed by the pre-developed algorithms and common guidelines. These approaches are helpful in most, but not all cases. Treatment of hospitalised patients is limited to the ...