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Potential role of anti-cytokine autoantibodies in the regulation of cytokine responses in infections and autoimmune diseases
(1999-09-27)
Anti-cytokine autoantibodies are serum proteins that bind cytokines and specifically interfere with measurements and biological activities of the corresponding cytokines. Plasma, sera, and CSF were obtained from patients ...
The matter of white and gray matter in cognitive impairment
(2017-08-03)
Cognitive impairment spans from minor subjective cognitive impairment to disabling dementia. Many biomarkers have been developed to monitor different aspects of cognitive impairment. Magnetic resonance imaging is the most ...
Deciphering microglia plasticity in glioma
(2019-01-11)
Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can ...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
and brain fitted a two-compartmentmodel in both adult and pups. Pharmacokinetics was age-dependent with a terminal elimination half-life of 7h in brain and plasma in pups compared to <0.5 h in adult rats. Brain exposure to roscovitine expressed as AUC brain...
TRIM21/ Ro52 in B cell pathology
(2013-01-25)
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell ...
Schizophrenia and criminal offending : risk factors and the role of treatment
(2008-10-31)
Background: The present thesis is written with the overall aim of
advancing knowledge of criminal offending among individuals with
schizophrenia. This may lead to better and more cost-effective methods
for the prevention ...
Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction
(2013-05-03)
Treatment of hospitalised patients is generally governed by the pre-developed algorithms and common guidelines. These approaches are helpful in most, but not all cases. Treatment of hospitalised patients is limited to the ...
Learning from primary immunodeficiencies to treat cancer
(2021-09-09)
The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent ...