Search
Now showing items 1-10 of 13
Cancer proteomics : characterisation of protein expression in human epithelial tumours
(1999-05-14)
Defining differences in protein expression between tumour cells of various degrees of malignancy is a first step in the development of markers for tumour diagnosis. In this thesis, the expression of multiple proteins in ...
The burden of back pain : evaluation of costs and health outcomes
(2020-11-27)
Background: Back pain is a leading cause of disability in the world. Beyond the negative impact on people’s health and quality of life, back pain is associated with substantial costs both within and outside the health care ...
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
(2008-10-17)
, inhibited adipocyte formation and enhanced osteoblast differentiation, while the inhibitor NAM had the opposite effect. In the second paper, osteoblastic cells from different origins, mouse, rat, and human, were treated with 1alpha,25(OH)2D3 and its analogue...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
by roscovitine was consistent with apoptosis. Loss of mitochondrial membrane potential, release of cytochrome c, active fragment of caspase-3 and cleaved PARP were observed in all three cell lines, however, the pattern of activation of caspase-2 and -8 showed...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, the number of human...
Studies of the synovial membrane in chronic rheumatic joint disease
(2006-04-26)
Background: The synovial membrane (SM) outlines the inner cavity of synovial joints except for cartilage surfaces. The SM is the target organ of immune-mediated responses in chronic arthritis, including rheumatoid arthritis ...
Regulation of Plasmodium falciparum virulence genes and immune response to surface antigens in placental malaria
(2011-11-15)
in women in their first pregnancy. Transcriptional regulation of var2csa as well as other var genes has been shown to be a complex and tightly regulated process. Our studies on duplicated var2csa paralogs in the P. falciparum strain HB3 revealed...
Interleukin-22 binding protein in multiple sclerosis and experimental inflammation models
(2017-10-20)
Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. Although the cause of the disease is unknown, several genetic and environmental risk factors have been identified. By ...
The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease
(2010-11-11)
/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. Congenital heart block (CHB) is a passively acquired autoimmune condition that may develop...
Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment
(2010-11-18)
The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss ...