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Human herpesvirus 6 infection after allogeneic stem cell transplantation
(1999-05-28)
Human herpesvirus 6 (HHV-6) is a lymphotropic virus mainly infecting T lymphocytes but also other types of cells. Seroepidemiological studies have shown that more than 90% of individuals older than 2 years are seropositive ...
Assessment of DNA damage, oxidative stress and inflammation in chronic kidney disease patients : and a clinical study of a dietary supplement
(2012-01-09)
Decreased kidney function is associated with higher levels of oxidative stress, inflammation and malnutrition. Chronic kidney disease (CKD) patients have a higher risk to develop cardiovascular disease, atherosclerosis and ...
PAK4 signaling in development and cancer
(2019-10-17)
Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ...
The perspective of being a family caregiver of a patient treated for oesophageal cancer : problems and needs
(2022-03-10)
=9.2; p=0.002). Those with a higher education level had less pain (MSD=11.2; p=0.01) and better physical function (MSD=9.1; p=0.006). Regarding patient-related factors, postoperative complications were negatively associated with family caregivers...
p53 guardian of the genome and target for improved treatment of leukemia
(2007-03-02)
P53 acts in several cellular processes as cell cycle checkpoints, DNA
repair senescence and the surveillance of genomic integrity. Wt p53
inhibits cancer processes by causing cell cycle arrest and apoptosis. P53
is ...
Toxicity and biocompatibility of nanoparticles, and studies on oxidative stress and DNA damage
(2015-05-11)
Oxidative stress is associated with several diseases, either as a cause or a consequence.
Chronic kidney disease (CKD) is one example of a disease in which elevated levels of
oxidative stress are frequently reported. ...
Erythrocyte amino acids in health and renal failure and their association to the IGF-I/IGFBP-1 axis
(1998-11-13)
Abnormalities in amino acids (AA) metabolism in uraemia have mainly been reported to occur in plasma and muscle. No investigation has been undertaken to evaluate the AA levels in plasma, muscle and red blood cells (RBC) ...
Lipids and autoimmunity in atherosclerosis and cardiovascular diseases
(2009-02-20)
Atherosclerosis is an inflammatory disease. The rupture of athrerosclerotic plaques is the major cause of severe cardiovascular disease (CVD), such as myocardial infarction (MI) and stroke. The stability of the plaque ...
Association between diet and treatment results in patients with rheumatoid arthritis and systemic lupus erythematosus
(2016-11-07)
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic autoimmune inflammatory diseases. The causes of these diseases are unknown and evidence indicates that a combination of both genetic and environmental ...
Interplay between mitochondria, primary cilium, diabetes and its complications
(2016-12-12)
Diabetes is one of the major health problems of the 21st century. Dysfunction of the insulin secreting pancreatic β-cell together with insulin resistance is central to the pathogenesis of type 2 diabetes mellitus (T2DM). ...