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Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects
(1999-05-13)
Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal ...
Heart failure : role of metabolic biomarkers, ejection fraction, and sex
(2018-10-30)
Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range ...
Chemical genetics and immunomodulation in Salmonella enterica serovar typhimurium infection
(2015-04-08)
Salmonella sp. are versatile bacteria that survive and replicate in a plethora of environmental
niches and hosts, including humans. The illnesses caused by various serovars in humans
range from mild gastroenteritis to ...
Genetic and immunological mechanisms regulating neuroinflammation
(2010-10-27)
Multiple sclerosis (MS) is the most common neurological disorder in young adults and imposes both health and socioeconomic burdens on society. The cause and aetiology of MS are incompletely understood and current treatments ...
Experimental therapeutics against malignant mesothelioma : investigations in vitro
(2009-11-20)
Malignant mesothelioma is a tumour of the mesothelium, a specialized tissue found in the pleura, pericardium, peritoneum, and tunica vaginalis testis. The tumour has strong etiological links to asbestos, with a latency ...
Diabetic glomerulopathy-natural history, intervention and prediction of complications
(2008-05-15)
Diabetes mellitus is one of the most common chronic diseases in childhood. Diabetic nephropathy (DN) is one of the threatening complications of diabetes that occurs in 30-40% of patients after 20 years duration of disease. ...
Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease
(2021-12-23)
Cardiovascular disease (CVD), with atherosclerosis as its main underlying pathology, is the most prominent cause of death worldwide. Progression and rupture of atherosclerotic plaques lead to potential adverse pathological ...
Tissue distribution studies and risk assessment of perfluoroalkylated and polyfluoroalkylated substances (PFASs)
(2013-05-15)
Perfluoroalkylated and polyfluoroalkylated substances (PFASs) represent a large class of man-made chemicals. These substances have emerged as environmental contaminants due to their extraordinary resistance to degradation, ...
Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia
(2019-12-11)
enrolment, 177(25.1%) and 83(11.8%) had high aspartate aminotransferase and alanine aminotransferase (ALT), respectively. Zidovudine or nevirapine containing regimens and viral load >1000 copies/mL were associated with elevated ALT. Twenty-four (3.4%) and 84...
Preoperative radiotherapy in rectal cancer : aspects on fractionation and timing of surgery
(2019-04-30)
and surgery within one week, SRT-delay - 5 Gy x 5 and surgery after 4-8 weeks or LRT-delay - 2 Gy x 25 and surgery after 4-8-weeks. Including centres could choose to randomise patients between three courses or between the two courses with 5 Gy x 5. Primary...