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Physiopathological aspects of NMDA transmission in the basal ganglia : in vitro and in vivo release studies
(1998-12-25)
to NMDA antagonists. This paper demonstrated that striatal NMDA receptor activation increases striatal DA, GABA and GLU release via different mechanisms.
A follow up study was then undertaken to test the sensitivity of the NMDA effects to D1 and D2...
The role of physical activity in the prevention of breast and endometrial cancer
(2000-09-15)
% higher risk of endometrial cancer than the most physically active women. Low occupational physical activity level during peri-menopausal years increased the endometrial cancer risk notably among women who were non-obese or smoked.
Among 3,347 women...
Epidemiological characterisation of Bordatella pertussis in Sweden, 1970-2004
(2007-01-26)
Worldwide, Bordetella pertussis causes some 50 million cases of pertussis, and an estimated 2-300,000 fatalities each year. In Sweden vaccination against pertussis was introduced in the 1950s using diphtheria-tetanus-whole-cell pertussis vaccine...
Toxicity of metal and metal oxide nanoparticles : the importance of physicochemical properties and cellular uptake
(2012-10-04)
The use of nanoparticles holds great promises in many technical as well as medical applications. However, development of new technologies, such as nanotechnology, is connected with uncertainties and risks. The same properties ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Investigation of the genetic basis of familial non-BRCA1/2 breast cancer
(2005-12-30)
cancer predisposing genes, BRCA1 and BRCA2. Mutations in these genes are responsible for the majority of large early onset breast and breast-ovarian cancer families. However, a large proportion of breast cancer families do not have mutations in BRCA1...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
. Therefore, we hypothesized that Bax, a pro-apoptotic member of the Bcl-2 family that is known to regulate intrinsic apoptosis, may play a key role in dexamethasone-induced retardation of bone growth. In chondrocytes, dexamethasone induced conformational...
Factors associated with brain tumor risk : with focus on female sex hormones and allergic conditions
(2008-09-03)
Every year approximately 1200 people in Sweden are diagnosed with a brain
tumor. The two main histological types of brain tumors, gliomas and
meningiomas, differ in terms of their localization, histology, prognosis,
and ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
Rheumatoid arthritis : pharmacological modulation of cytokines : aspects of clinical response and endocrine regulation
(2006-01-06)
Rheumatoid arthritis (RA) is a systemic inflammatory disease primarily affecting the joints. In the pathogenesis several cells of the immune systeme and messengers of the immune systeme, cytokines, are important. In this ...