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The role of physical activity in the prevention of breast and endometrial cancer
(2000-09-15)
The aim of this thesis was to explore through epidemiologic studies the role of physical activity in preventing breast and endometrial cancer in women.
First, we assessed risk for endometrial (Paper I) and breast ...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and ...
Chorangiomas : histopthological, clinical and genetic studies
(2017-10-20)
Chorangioma (CA), although, is the most common non-trophoblastic, vascular, tumor-likelesion of the placenta with incidence approximately 0.5-1% of all examined placentas, the specific etiology and genetic background of ...
Bringing order to disorder : structural and functional analysis for development of strategies to target MYC
(2014-09-05)
Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
Eicosanoids in cancer : new therapeutic targets in neuroblastoma
(2011-12-22)
Cancer is one of the most common causes of death for both children and adults in developed countries. Neuroblastoma is a cancer of the sympathetic nervous system that affects infants and young children. Neuroblastoma tumors ...
Human cytomegalovirus in congenital infections and embryonal malignancies of the nervous system
(2009-10-02)
Cytomegalovirus (CMV) is a herpesvirus that may cause severe or even fatal disease in immunocompromised patients as well as severe developmental disturbances in foetuses infected in utero. In contrast, only mild symptoms ...