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Prader-Willi syndrome : diagnosis and effects of growth hormone treatment
(1998-10-30)
Prader-Willi syndrome (PWS) is a rare neurogenetic disorder characterised by hypotonia (especially pronounced in the perinatal period) with "failure to thrive", hypogonadism, hypoventilation, dysmorphic features, final ...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
p53 guardian of the genome and target for improved treatment of leukemia
(2007-03-02)
P53 acts in several cellular processes as cell cycle checkpoints, DNA
repair senescence and the surveillance of genomic integrity. Wt p53
inhibits cancer processes by causing cell cycle arrest and apoptosis. P53
is ...
Survival and renal function after acute kidney injury : epidemiological and biomarker studies
(2018-01-10)
significantly higher crude mortality at one (48.4% vs 24.6%) and five years (61.8% vs 39.1%) compared to non-AKI patients. CKD and ESRD were significantly more common in AKI survivors at one year (adjusted incidence rate ratio (IRR) 7.6 and 22.5 respectively...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
and Results: In 6,711 patients undergoing coronary artery bypass grafting (CABG), already moderate RI was associated with mortality within 30 days of CABG (Odds ratio (OR) 1.4, (95% Confidence Interval (CI), 1.2 to 4.8) (Study I). Among those patients who...
Gastric bypass : positive and negative health effects
(2017-12-15)
Obesity is a major health problem worldwide. It is preventable in theory, but in practice no country has been able to stop the development of increasing obesity. The only available treatment with sufficient long-term effect ...
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
(2008-10-17)
, 2-methylene-19-nor-(20S)- 1alpha,25(OH)2D3 (2MD). Species-dependent effects on cell growth and alkaline phosphatase (ALP) activity were clearly seen. In the third paper, we found that the expression of Interleukin-6 (IL-6) receptor increased during...
Pathophysiological factors and genetic association in endometriosis
(2011-01-27)
Introduction: Endometriosis is a common benign gynecological disease where endometrial tissue forms lesions outside the uterine cavity. Endometriosis is estimated to affect about 10% of women of reproductive age, rising ...
Coping and emotional well-being in patients with chronic heart failure
(2015-08-19)
Background: Chronic heart failure (CHF) is a serious illness, with a profound impact on the patient. Poor health-related quality of life (HRQoL) as well as anxiety and depression are prevalent in CHF and predict mortality ...
Mechanisms of adaptation to the fitness cost of antibiotic resistance
(2007-05-18)
The dissemination and persistence of antibiotic resistance, is not only
depending on the volume of drugs used but also on the resistance
mechanisms effect of bacterial fitness (reproductive ability). Fitness is
a multifactorial ...