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Experimental bacterial meningitis : studies on immunopathogenesis and immunoregulation
(1998-05-14)
-inflammatory response, while S. pneumoniae-infected rats responded with mixed pro- and anti-inflammatory responses.
Brains of infant rats challenged with Hib i.p. resulted in the time-dependent mRNA of expression of MIP-2, MlP-la, MCP-I and RANTES, which was maximal...
Studies of mRNA transport and localization
(2011-05-17)
RNA trafficking. In paper 3 we report that CBF-A is involved in transport and localization of protamine 2 mRNA during spermatogenesis. CBF-A binds to the conserved RTS in the protamine 2 mRNA 3’ UTR and in round spermatids, CBF-A accompanies protamine 2 m...
Distal radius fractures : epidemiology and aspects of surgical management
(2020-11-06)
Distal radius fractures (DRFs) are the most common fractures treated by physicians. About 20% of all DRFs are treated surgically. The main surgical methods are volar plate fixation, external fixation and percutaneous ...
Early diagnosis and risk stratification in patients with symptoms suggestive of acute coronary syndrome
(2018-10-25)
positive or a negative test, neither at 90 (n=1 [1.1%] vs. n=1 [0.2%]), nor at 365 days (n=2 [2.1%] vs. n=4 [0.7%]) of follow-up. In total, there were 9 (0.9%) deaths and 10 (1.1%) MIs within 365 days. The one-year rates of death (1.3%) and MI (0.5%) in a...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Customization of tamoxifen therapy : not only a dream
(2011-09-06)
cells. LCC2 cells were also dependent on RARA for maintenance of viability. Primary validation of the impact of RARA on survival, in the previously described cohort, revealed a correlation between high RARA expression and reduced relapse-free survival...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
Chromatin remodelers and their roles in chromatin organization
(2012-11-20)
form a “beads on a string” structure, which can be folded into higherorder structures that allow an extensive degree of DNA compaction. This compaction is so effective that 2 meters of DNA can fit into the human cell nucleus with a diameter of only 10...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ...
Ready to pull : force transmission during vascular development
(2019-12-17)
model. In Paper IV, we indicate that AmotL2 connects junctional VE-cadherin and radial actin filaments to the LINC complex in the nuclear membrane. Deletion of AmotL2 impairs the formation of radial actin filaments and the flow-induced alignment...