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Identification and characterization of allergen components of the opportunistic yeast Malassezia furfur
(1998-05-15)
The yeast Malassezia furfur (Pityrosporum orbiculare) is a member of the human normal skin microflora. It has been suggested that this yeast plays an important role in the pathogenesis of atopic dermatitis (AD). In 40-65% ...
Epidemiology, risk and protective factors of self-immolation : a study from Iran
(2013-04-04)
Background: Suicide by self-burning (self-immolation) is one of the suicide methods that is far more common in low-middle income countries than in high-income ones. Iran is one of the countries that has a high rate of ...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
p53 guardian of the genome and target for improved treatment of leukemia
(2007-03-02)
P53 acts in several cellular processes as cell cycle checkpoints, DNA
repair senescence and the surveillance of genomic integrity. Wt p53
inhibits cancer processes by causing cell cycle arrest and apoptosis. P53
is ...
Role of PfATP6 and pfMRP1 in Plasmodium falciparum resistance to antimalarial drugs
(2009-05-11)
) has been suggested to be a target for ART. Multidrug resistance proteins (MRPs) are known to be related with multidrug resistance in many organisms. The P. falciparum Multidrug Resistance Protein 1 (pfMRP1) has been suggested to have a role...
Detection and epidemiologic subtyping of Legionella pneumophilia using DNA-based molecular methods
(2003-11-14)
Legionella pneumophila causes 2 - 6 % of hospitalised pneumonia cases. Several community- and hospital-acquired outbreaks have been reported over the years. Legionnaires' disease (LD) or legionellosis is also a frequent ...
A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy resistance. However...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of death from infectious disease...
Healthcare financing challenges and opportunities to achieving universal health coverage in the low- and middle-income country context
(2020-02-05)
estimated the impoverishment effect of OOP payments using both the national (cost of basic need approach) and the international (1.90 International dollar per person per day) poverty line. For study II, 557 informal workers were surveyed during 2010...
Uveal melanoma : epidemiological and clinical aspects
(2005-09-23)
.108). The annual decrease in incidence rate was estimated to 1% (95% Cl: 0.81.2) in males and to 0.7% (95% Cl: 0-1.3) in females. The 5year observed and relative survival rates were 60% and 70% respectively, with better survival in younger age groups and later time...