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A study of the cell adhesions molecules, E-cadherin and C-CAM, and the intermediate filaments, nestin, in craniofacial and tooth development
(1998-03-27)
Cell adhesion molecules (CAMs) are involved in cell migration, morphogenesis, and cell differentiation within the embryo, and later in the maintenance of the multicellular organism. The aim of the present investigation was ...
Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression
(2021-01-12)
formation of complexes between CTCF and PARP1, two master regulators of the genome, to increase the amplitude of circadian gene expression. In Paper II we took an advantage of the novel, ultrasensitive Nodewalk technique to explore the stochastic nature...
Genetic and immunological mechanisms regulating neuroinflammation
(2010-10-27)
Multiple sclerosis (MS) is the most common neurological disorder in young adults and imposes both health and socioeconomic burdens on society. The cause and aetiology of MS are incompletely understood and current treatments ...
Insulin-like growth factor 1 receptor, novel functions and future possibilities
(2017-09-01)
Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation...
Are we using antibiotics responsibly? Assessing antibiotic use in rural Shandong province, China
(2020-02-19)
Background: Tackling the misuse and overuse of antibiotics is critical both for global sustainable development and for reducing social inequalities in the world. The World Health Organisation Global Action Plan on antimicrobial ...
Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase
(2001-05-02)
in an ADH1 enzyme through the generation of the double mutant ADH1C2Leu57Asp/Aspll5Arg. This was partly successful since ADH3-like kinetic features for 12hydroxydodecanoate and ethanol was monitored. However, the ADH1C2Leu57Asp/Asp115Arg displayed no HMGSH...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
neural stem cells (NSCs). By applying different metabolic conditions in vitro, we showed that hypoxia and 2-Deoxy-D-glucose increased acetylation of CtBP2 in proliferating NSCs. Additionally, 1% oxygen treatment resulted in altered homodimerization of Ct...
Estimation of gestational age by ultrasound and extreme prematurity
(2012-05-16)
Accurate estimation of the gestational age of the fetus is a key assessment made by providers of obstetric care during pregnancy, since decisions concerning management strategies are dependent on this estimate. Thus, the ...
Getting in and out of shape : relevance for organ formation and cancer
(2014-09-11)
A central question during development is how single cells form functional multi-cellular organ structures. The high reproducibility indicates intricate synchronization of cellular behaviors such as migration, proliferation ...
Expression and function of TRP channels in peripheral sensory neurons
(2009-05-19)
and adult stages. Cellular localisation studies of selected channels in the DRG further revealed expression in different neuronal subtypes. TRPC1 and TRPC2 were primarily found in large sized mechanosensitive neurons, TRPC3 was exclusively found in non...