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Side-chain oxidized oxysterols as metabolic regulators in vivo
(2017-02-28)
Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half- life and their ability to pass lipophilic membranes easily, and they are considered as important intermediates in the excretion ...
Unravelling molecular mechanisms underlying therapy resistance in cutaneous melanoma
(2016-09-07)
For many years the standard treatment of advanced metastatic
melanoma with chemotherapeutic agents, including temozolomide (TMZ)
and dacarbazine (DTIC), has been unsuccessful. The paradigm shift in
melanoma treatment ...
MHC class I restricted and antigen-specific TCRs against viral and tumor-associated antigens (TAAs) for future biological therapy
(2017-04-07)
Adoptive cellular immunotherapy (ACT) refers to the process of transferring immune cells (autologous or allogeneic) directly to the host as a treatment for cancer or infectious diseases. The effector cells could be ...
Natural killer cells in cancer : studies on migration and cytotoxicity
(2014-05-08)
The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. ...
Genetic studies of colorectal cancer
(2007-02-02)
Colorectal cancer is the third most commonly diagnosed cancer worldwide with an incidence rate of over 1 million cases per year. A genetic contribution has been suggested to be involved in around 35% of all colorectal ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ...
To kill two birds with one stone : targeting myeloid cells in cancers
(2015-05-08)
Cancer progression is often accompanied by chronic inflammation and severe impairment of the immune system. In recent years, therapies eliciting tumor-specific immunity have resulted in striking tumor control and survival ...