Search
Now showing items 1-10 of 21
Gastroesophageal reflux does not alter effects of body mass index on risk of esophageal adenocarcinoma
(2015-10-02)
Background & Aims: A history of high body mass index (BMI) is strongly associated with risk of esophageal adenocarcinoma (EAC). We investigated whether gastroesophageal reflux is involved in this association.
Methods: ...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...
Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture
(2005-11-11)
Fragmentation of elastin, loss of smooth muscle cells (SMCs) and accumulation of inflammatory cells are the histological landmarks of abdominal aortic aneurysm (AAA). In larger aneurysms, an intraluminal thrombus is almost ...
Women’s experiences of fetal screening for Down’s syndrome by means of an early ultrasound examination
(2005-03-25)
The general aim of this thesis was to explore women’s reactions to and experiences of fetal screening for Down’s syndrome (DS) by means of an ultrasound examination, including measurement of fetal nuchal translucency (NT). ...
Proteomic analyses of bioactive molecules in health and disease
(2008-05-23)
After the mapping of genomes and knowing the blueprints of the possible gene products, focus is shifting from genomics to proteomics. Proteome analyses can be used for diagnosis, prognosis and monitoring of diseases and ...
Bicuspid aortic valve-associated aortopathy unraveling the molecular signature
(2013-05-22)
Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysm compared with individuals with a tricuspid aortic valve (TAV). A crucial factor involved in vascular remodeling during ...
Studies on the regulation of hepatic and intestinal lipid metabolism
(2013-09-25)
Disturbances in the lipid homeostasis can result in a wide variety of different diseases and symptoms. This thesis is focused on the regulation of cholesterol metabolism and its relation to atherosclerosis development, and ...
Non-invasive analysis of leukotrienes as biomarkers of airway inflammation : method development and clinical applications
(2008-09-26)
Asthma and chronic obstructive pulmonary disease (COPD) are two common
diseases characterized by chronic airway inflammation, but the
inflammation in asthma is different from the one in COPD. In addition,
asthma is a ...
Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection
(2006-04-14)
B cells of HIV-1-infected patients have both phenotypic and functional dysfunctions which may be important in HIV-1 pathogenesis. Immune activation during HIV infection is an essential part of the body s defense against ...
Post-translational and therapy-induced modifications in rheumatoid arthritis
(2008-05-09)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial proliferation and excessive mononuclear infiltration leading to destruction of bone and cartilage, with subsequent joint deformities and ...