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Identification of tumor suppressor genes using the approach of gene inactivation test
(2006-05-26)
Epithelial cancers are the most prevalent and lethal diseases in the world. They cause more than 80% of all cancer deaths. Development of these tumors is a complex process involving more than 100 genes from different ...
Molecular genetic studies of psoriasis susceptibility in 6p21.3
(2005-02-18)
Psoriasis is a common and chronic skin disease with multifactorial background. It affects approximately 2% of the Swedish population and is characterized by inflammatory and scaly lesions. The aetiology of psoriasis is not ...
Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis
(2004-05-06)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in demyelination, axonal loss and neurological deficits. The aetiology is unknown, however, immunopathological events, ...
Brain opioid mechanisms in amphetamine induced behaviours
(2009-09-04)
Amphetamine abuse and dependence are global health problems, affecting large numbers of individuals. Despite extensive research efforts, there has been no evidence-based pharmacotherapy available for amphetamine dependence. ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
The role of EBNA binding proteins in cell transformation
(2013-05-06)
Epstein-Barr virus (EBV) infects majority of the human population and maintains sub-clinical infection. However, under certain conditions it is associated with several B-cell malignancies, such as Burkitt lymphoma, Hodgkin’s ...
A personalized approach to chronic rhinosinusitis with nasal polyps : based on biomarkers, phenotypes and new surgical thinking
(2020-04-27)
Chronic rhinosinusitis (CRS) is a prevalent disease causing a substantial burden for the patient and the society. CRS is divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). Based on current knowledge on ...
Studies on the links between white adipose tissue phenotype and the circulatory system
(2021-12-22)
Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ...
Vascular repair mechanisms : experimental, physiological and clinical studies
(2009-05-14)
Cardiovascular disease is the leading cause of global mortality and physical disability mainly due to the complications of atherothrombosis such as myocardial infarction or stroke. Surgical treatment directed to prevent ...
Expression profiling of blood vessels in pericyte deficiency and diabetes
(2010-11-11)
The kidney glomerulus is essential for the filtration of waste products from the blood into the urine and in controlling the volume and composition of body fluids. Injury to the glomerulus can lead to altered glomerular ...