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p73 : regulator of differentiation and apoptotic cell death
(2007-05-04)
Neoplasia is characterized by cells' loss of self-control due to
deregulated apoptotic and cell proliferation pathways. Anticancer
treatments aim to induce either cell cycle arrest or apoptosis, and these
effects are ...
Regulators of glucose and lipid metabolism in skeletal muscle and serum : implications for obesity and type 2 diabetes
(2012-11-01)
Type 2 diabetes mellitus (T2DM) has become a growing worldwide problem of public health importance. Insulin resistance is commonly associated with obesity and a key factor mediating the progression to T2DM. The failure of ...
Studies on the mechanisms of action and physiological relevance of SOCS proteins
(2011-10-27)
Understanding systemic biological pathways and the key cellular mechanisms that dictate disease states, drug response, and altered cellular function in metabolic disorders is a significant challenge. Research in the last ...
Central and peripheral mechanisms regulating energy and glucose homeostasis
(2013-05-23)
Obesity is a major health concern across the globe and is often associated with insulin resistance and type 2 diabetes. The coupling of ene rgy intake and expenditure is tightly regulated by central and peripheral mechanisms ...
Short and long-term regulation of autophagy
(2020-09-04)
Autophagy is a conserved catabolic pathway triggered by stress conditions in which portions of the cytoplasm, damage organelles, misfolded proteins and intracellular bacteria are delivered and degraded in the lysosome/vacuoles. ...
The mechanism of action of SOCS2 and its role in metabolism and growth
(2013-05-23)
A well-known function of Growth Hormone (GH) is the regulation of postnatal longitudinal growth but it also affects other biological processes, for instance metabolism and inflammation. Actions of GH are tightly regulated ...