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Cumulative assessment of persistent organic pollutant toxicity in vivo
(2011-05-02)
Humans are continuously exposed to a multitude of compounds present in the environment and in food. A major challenge in risk assessment is to determine the degree of exposure to multiple chemicals and the hazards associated ...
Novel treatment strategies and regulation of IgE-mediated allergic disease
(2008-02-15)
Allergic symptoms such as rhinoconjunctivitis, asthma or gastrointestinal
symptoms, triggered by inhaled or ingested allergens cross-linking
allergen-specific IgE on mast cells or basophils, are defined as
IgE-mediated ...
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
(2007-10-05)
The growth hormone (GH) / insulin-like growth factor (IGF) family of
ligands, binding proteins and receptors play multiple roles in cell
growth, metabolism and development. In addition, numerous studies have
demonstrated ...
Adenosine receptor signaling and the activation of mitogen-activated protein kinases
(2002-10-18)
The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular ...