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Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Innate regulation of the adaptive immune system during autoimmunity
(2015-05-22)
Immune activation comprises multiple biological checkpoints to ensure proper
and regulated effector functions. Phagocytes such as macrophages, dendritic
cells and neutrophils have important functions during inflammation, ...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...