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Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls
(1997-01-24)
), the nondioxin-like 2,4,5,2',4',5'-hexachlorobiphenyl (PCB 153) and TCDD can act as tumour promoters in the livers of female Sprague-Dawley rats. PCB 126 treatment is about 10% as efficient as TCDD in tumour promotion activity, which is in agreement with a toxic...
Molecular and ultrastructural analysis of Tpr, a nuclear pore complex-attached coiled-coil protein
(2003-05-02)
that tethers Tpr to the NPC was found to be a nucleoporin termed Nup 153. Whereas RNAi-promoted loss of Tpr had no effect on correct incorporation of Nup153 into the NPC, cellular depletion of Nup153 by RNAi abolished NPC binding of Tpr and caused...
Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans
(2003-05-16)
of the BR3 gene to occur cotranscriptionally.
Injection of an antibody to the NPC component Nup153 caused accumulation of both mRNA and rRNA in the nucleoplasm. Analysis by EM revealed that the mRNP particles bound to the top of the basket structure...
Characterizing life-long human exposure to persistent environmental pollutants
(2011-11-18)
) and contaminant concentrations in food (1998 - 2004) and breast milk (2000 - 2006). A food concentration database was developed for the assessment of food frequency questionnaire (FFQ)-based PCB153 exposure in middle-aged and elderly women (born 1914 - 1948...
Weekday of cancer surgery in relation to prognosis
(2018-10-11)
·88) for oesophagogastric cancer, 1·49 (1·17 to 1·88) for liver/pancreatic/biliary cancer and 1·53 (1·44 to 1·63) for colorectal cancer. Excluding mortality during the initial 90 days of surgery made little difference to these findings, and all-cause mortality was similar...
Persistent organic pollutants and bone tissue : studies in wild and experimental animals
(2007-11-09)
Since the mid 1900s, there has been a dramatic increase in the number of
osteoporotic-related fractures in the industrialised world. The reason
for this is unknown, but there could be a link between the increased use
and ...
Molecular consequences of cellular UDP-glucose deficiency
(2004-05-21)
of the transcription factors ATF6 and XBP-1/TREB5, thereby inducing expression of ER chaperones and the transcription factor CHOP/GADD 153. However, a decrease in the cellular levels of UDPG did not induce the expression of CHOP/GADD 153, nor the activation of ATF6...
Liver tumour promoting effects by polychlorinated biphenyls
(1998-11-13)
congeners 3,4,5,3',4'-pentachlorobiphenyl (PCB126), 2,3,4,3',4'pentachlorobiphenyl (PCB105) and 2,4,5,2',4',5'-hexachlorobiphenyI (PCB153), representing different types of chlorine substitution in the ortho position, were studied and the results were...
Persistent organic pollutants in Swedish first-time mothers and effects on infant health
(2013-11-08)
-153 (1% per year). High maternal age and fast weight loss after delivery predicted higher levels of PCBs and PCDD/Fs in breast milk, whereas a high pre-pregnancy body mass index and large weight gain during pregnancy predicted lower levels. Women who...