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Hemophagocytic lymphohistiocytosis and associations with malignancies
(2023-05-10)
In immune homeostasis, natural killer cells and cytotoxic T cells are responsible for clearance of virus-infected and tumor transformed cells, but also for turning off the immune response. Patients with familial hemophagocytic ...
Apoptosis, cellular division or mitotic catastrophe? Effects of kinase inhibition and DNa damage in lung cancer cells
(2007-01-07)
Non-small cell lung cancer (NSCLC) cells are generally characterized by a
low response to conventional anti-cancer agents, such as DNA-damaging
drugs. Treatments that induce DNA damage relies on cellular signalling
resulting ...
In vitro models aiming for fertility preservation
(2018-10-11)
Fertility preservation is considered a great hope to people suffering from infertility as a consequence of developmental or genetic cause, a disease itself or its treatments sequelae. In vitro models are fundamental to ...
Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed
(2012-04-04)
Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. ...