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Peer learning on clinical wards : supervision, student activities and the learning environment
(2022-11-11)
Introduction: Worldwide, a growing number of healthcare students require clinical environments for learning. Multiple students are placed on clinical wards simultaneously with one supervisor to meet this demand. This can ...
LXR and aromatase knock-out mice : animal models providing insight into human diseases
(2009-01-01)
In our characterization of mouse strains carrying mutations in nuclear
receptor and aromatase genes we have found phenotypes which resemble four
human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome
(SS), ...
Studies on the phenotype of LXRβ-/- mice : from malabsorption to amyotrophic lateral sclerosis
(2008-10-06)
Liver X Receptors, LXRalpha and LXRbeta (NR1H2) are nuclear receptors
belonging to the superfamily of ligand-activated transcription factors
with a key role in the control of lipid and glucose metabolism. Studies
of the ...
Novel aspects of metabolic regulation and inflammation in human adipocytes
(2015-04-28)
The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. The aim of this thesis was to investigate the ...
LXR regulation of hepatic gene expression and pituitary dependent hormones
(2009-03-06)
The liver X receptors (LXRs) are ligand activated transcription factors
involved in the regulation of metabolic genes. LXRs are considered
potential drug targets to treat metabolic disorders, however, unwanted
side ...
Estrogen and liver X receptors in human disease
(2006-11-10)
The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated ...
Studies of LXR and CIDEA function in human adipocytes
(2012-01-18)
Obesity, defined as a body mass index of 30 or above, is the result of an imbalance of energy intake and energy expenditure. In the last decade, the obesity prevalence has truly reached epidemic proportions with major ...
Nuclear receptor and Wnt function in developing dopaminergic neurons
(2007-01-26)
The progressive degeneration of dopaminergic neurons in the substantia
nigra is one of the major pathological events associated with Parkinson’s
Disease. Dopaminergic (DA) cell replacement therapy has emerged in recent
years ...
Dietary effects on gene regulation and function in human adipose tissue in obesity
(2007-05-04)
Obesity is an excess of body fat that develops from both genetic and environmental factors, leading to a disturbed balance between energy intake and energy expenditure. It is closely associated with insulin resistance, ...
The antiproliferative role of the liver X receptors in breast and colorectal cancer
(2013-05-14)
The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily of ligand activated transcription factors and have functions as regulators of lipid and glucose metabolism, as well as inflammatory ...