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Investigating the treatment of metastatic breast cancer : real-world evidence on treatment patterns, safety and efficacy
(2022-05-25)
Metastatic breast cancer is an incurable disease causing a spectrum of symptoms and leading
to a continuous deterioration of performance status and quality of life. It is a heterogeneous
disease, with survival being ...
Oxidative stress in experimental traumatic brain injury
(2015-05-13)
Traumatic brain injury (TBI) is a leading cause of death and disability among the young population in the industrialized world. The injury consists of immediate damage to the brain tissue, followed by a secondary response ...
Development of radiofrequency pulses for fast and motion-robust brain MRI
(2020-08-21)
This thesis is based on three projects and the three scientific articles that were the result of each project. Each project deals with various kinds of technical software development in the field of magnetic resonance ...
Decoding the heterogeneity of skin in homeostasis and regeneration at single-cell resolution
(2018-12-20)
The skin plays a critical role in securing homeostasis in the mammalian body. Its epidermis forms a tight barrier, which separates the internal from the external environment, thereby shielding the body from physical and ...
High-resolution diffusion-weighted brain MRI under motion
(2014-10-30)
Magnetic resonance imaging is one of the fastest developing medical imaging techniques. It provides excellent soft tissue contrast and has been a leading tool for neuroradiology and neuroscience research over the last ...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...