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Muscular aging and its relation to physical activity and function : longitudinal and cross-sectional analyses
(2021-11-09)
With age, muscle mass decreases and muscle function and strength decline, which is associated with loss of independence, hospitalization, morbidity and mortality. The aim of this thesis was to investigate the mechanisms ...
Adenosine receptor signaling and the activation of mitogen-activated protein kinases
(2002-10-18)
The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular ...
Hypospadias : gene mapping and candidate gene studied
(2009-08-28)
Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of ...
Modulation of hormone signaling by cadmium : from molecular mechanisms to health implications
(2013-09-26)
Cadmium is a toxic metal classified as human carcinogen and ubiquitously found in our environment mainly from anthropogenic activities. Exposure to cadmium has been associated with increased risk of certain hormone-dependent ...
Estrogen actions in the growth plate cartilage
(2020-03-24)
Estrogens may influence bone growth locally or systemically via the estrogen receptors alpha (ERα), beta (ERβ) and G protein-coupled estrogen receptor 1 (GPER-1). In Paper I, our study showed that the treatment of ...
Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption
(2017-02-06)
The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...
Cerebrospinal fluid biomarkers in twins with schizophrenia and bipolar disorder
(2015-08-27)
Previously identified cerebrospinal fluid (CSF) biomarkers were studied in 37 twins with
schizophrenia or bipolar disorder to determine their genetic and environmental properties.
Further, comorbidities and sibling risks ...
Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases
(2006-05-12)
Propionibacterium acnes (P. acnes) is an anaerobic, Gram-positive bacterium that belongs to the normal microflora. The skin is the major habitat but it can also be found in other body regions. P. acnes plays an important ...
Nasal and bronchial testing as well as treatment of patients with airway hyperresponsiveness and inflammation focusing on the united airway concept
(2008-09-12)
Allergic and non-allergic rhinitis and asthma is a global health problem on the increase that causes major illness and disability worldwide, and also results in a large financial burden on society. This thesis contains six ...
Development of a Sel-tag for multimodality imaging and studies of mammalian thioredoxin reductase 1
(2010-09-24)
Selenocysteine (Sec; U in one-letter code), the 21st amino acid existing in all selenoproteins, has unique biochemical properties due to its selenium atom, including a low pKa and a high reactivity with many electrophilic ...