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The dimensions of human and murine CD8 T lymphocyte diversity
(2024-01-12)
The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification ...
Mechanisms of cancer cell death by mutant p53-reactivating compound APR-246
(2021-02-11)
Tumor suppressor TP53 is the most frequently mutated gene in cancer. A majority of TP53 mutations result in a mutant p53 that disrupts its DNA binding capabilities but may also acquire novel gain-of-function activities ...
Womens evaluations of intrapartum and postpartum care
(2007-09-21)
The overall aim of this thesis was to increase understanding of women's evaluations of intrapartum and postpartum care. Evaluations of specific aspects of care, general assessments of intrapartum and postpartum care, and ...
Cognitive behavioral therapy for children and adolescents with dental phobia
(2016-11-08)
Background: Dental phobia is a disabling and clinically significant fear that interferes with the dental care necessary for a child’s or adolescent’s well-being. In fact, the definition of oral health in children and ...