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Association between levels of sex hormones and risk of esophageal adenocarcinoma and Barrett’s esophagus
(2020-03-18)
Background & Aims: Esophageal adenocarcinoma (EAC) occurs most frequently in men. We performed a Mendelian randomization analysis to investigate whether genetic factors that regulate levels of sex hormones associated with ...
Influence of oxidative stress on aryl hydrocarbon receptor signaling
(2013-05-13)
The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) super-family of transcription factors. The ...
Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia
(2017-03-02)
Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, ...
Extrahepatic cytochrome P450s : relation to cancer susceptibility
(2003-09-19)
Cytochrome P450 (CYP) enzymes in extrahepatic tissues may play important roles in regulating the capacity of individual cells to metabolize environmental carcinogens and hormones. In this thesis, we characterized the ...
Risk factors and outcomes in inflammatory myopathies
(2023-05-04)
Idiopathic inflammatory myopathies (IIM) are complex autoimmune diseases associated with high morbidity and mortality. Although knowledge about the pathogenic mechanisms underlying IIM is improving, limited data are available ...
Regenerating the brain : stem cell differentiation and cholinergic dysfunction in Alzheimer disease
(2014-05-15)
Hippocampal neurogenesis in the adult brain is important for learning and memory processes, which are heavily affected in Alzheimer disease (AD). Thus, targeting processes that could stimulate neurogenesis is a logical ...