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Clinical aspects of Lynch syndrome
(2020-03-05)
Colorectal cancer is the second most common cancer in women and the third most common cancer in men worldwide, with 1.8 million new cases and almost 861000 deaths in 2018. Approximately 5–10% of the annual CRC burden can ...
Human ISL1+ ventricular progenitors self-assemble into an in vivo functional heart patch and preserve cardiac function post infarction
(2021-07-01)
The generation of human pluripotent stem cell (hPSC)-derived ventricular progenitors and their assembly into a 3-dimensional in vivo functional ventricular heart patch has remained an elusive goal. Herein, we report the ...
An ependymal cell quest : identification and functional role of spinal cord neural stem cells
(2014-03-07)
Few injuries have as profound and long-lasting consequences as spinal cord injury. The primary areas of impaired function typically include sensation, mobility, bladder, bowel and sexual function. The economic, social and ...
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
(Nature Publishing group, 2022-08-18)
Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...