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Neutrophil subsets in airway inflammation and hyperreactivity
(2019-11-06)
Neutrophils are part of the first lines of defence against invading microbes. They play an essential role in antimicrobial host defence by recognizing microorganisms through the various receptors that can be expressed on ...
Fecal calprotectin in children with special reference to inflammatory bowel disease
(2007-03-09)
This thesis aims to study the clinical usefulness of fecal calprotectin as a noninvasive marker of colonic inflammation in children with suspected or confirmed chronic inflammatory bowel disease (IBD). Calprotectin, a ...
Activating proto-oncogene mutations in human cutaneous melanoma
(2005-05-13)
Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary ...
Bacterial gene expression inhibition with antisense peptide nucleic acids
(2005-05-12)
Regulated gene expression is widely useful for gene function studies and as a means to control genes important in disease. There are many methods for regulating the expression of genes, and one approach is to use antisense ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Expression and regulation of antimicrobial peptides in mucosal immunity
(2012-10-25)
Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. ...
Novel aspects on osmolality and plasma sodium during pregnancy and labour
(2017-11-21)
This thesis was designed to study causes and effects of changes in plasma sodium and osmolality during pregnancy and labour. The physiological changes of early pregnancy include reduction in plasma sodium and osmolality, ...
Malaria and polypeptides of Plasmodium falciparum at the infected erythrocyte surface
(2016-03-11)
Malaria is one of the top three most lethal infectious diseases in the world after tuberculosis
and HIV. The disease is caused by intracellular parasites of the genus Plasmodium spp. To
date, five Plasmodium spp have ...
Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models
(2016-05-20)
The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination ...
The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci
(2003-03-07)
In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma ...