Search
Now showing items 1-5 of 5
Molecular mechanisms and targets of new anticancer treatments
(2019-02-06)
The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies ...
Fibrinogen-binding proteins from Staphylococcus aureus
(2020-06-08)
Staphylococcus aureus produces a large number of proteins that specifically bind to molecules from plasma or from the human extracellular matrix where they are involved in processes associated with the colonization of the ...
Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids
(2006-10-20)
Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells ...
Antiapoptotic effect of ouabain in renal cells exposed to toxic glucose levels
(2019-11-06)
Diabetes mellitus is a group of metabolic diseases that causes enormous social and economic burden. The kidney is the filtration organ that produces urine and is the primary target of diabetic complications, a condition ...
Nephroprotective effect of the cardiotonic steroid ouabain
(2014-04-30)
It has been shown that Na,K-ATPase (NKA) is a signal transducer. Our group described the anti-apoptotic effect of ouabain to the signaling function of NKA. Exposure of renal cells to low concentrations of the highly specific ...