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Set for life? Socioeconomic conditions, occupational complexity, and later life health
(2018-02-22)
Life expectancy has increased in the western parts of the world and more people reach old age. Some groups of people have benefitted more of the increase in life expectancy and have better health than others. Because of ...
Aortic valve replacement with stentless bioprostheses : prospective long-term studies of the Biocor and the Toronto SPV
(2002-03-22)
Background: Aortic valve disease is increasing among the elderly and aortic valve replacement is the most common cardiac surgical valve procedure in adults. Aortic stenosis (AS) is often associated with left ventricular ...
Molecular regulators of glucose and lipid metabolism in skeletal muscle
(2012-04-27)
Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis. Another key feature of a healthy skeletal ...
Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA
(2008-09-05)
Nucleoside analogs are modified nucleosides used in treatment of cancer
and viral infections. They are dependent on intracellular phosphorylation
to be pharmacologically active. Deoxyribonucleoside kinases catalyze ...
The role of 5'-nucleotidases and deoxynucleoside kinases in responses to nucleoside analogues
(2010-04-30)
The efficacy of nucleoside analogues (NAs) in treating several
hematological malignancies, solid tumors and viral infections is limited
primarily by side-effects and the development of drug resistance. The
aims of the ...