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Proteome studies, with emphasis on the kidney glomerulus
(2012-03-22)
Proteomics aims to link genes to protein expression and function. Proteomics is a very versatile and technology-dependent discipline and the development of mass spectrometry-based proteomics has advanced the understanding ...
Tartrate-resistant acid phosphatase/ACP5 as a driver of cancer : dissection of its oncogenic mechanisms and identification of small molecule inhibitors
(2017-11-22)
Cancer patients diagnosed with metastasis have an increased risk of dying. To be able to predict and target tumors with an increased risk for spreading, underlying molecular events need to be better dissected and understood. ...
Mimicking the action of ribonucleases : studies on RNase A and design of PNA based artificial enzymes
(2015-10-09)
A 3’-deoxy-3’-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. Despite that both the vicinal 2-hydroxy ...