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Risk factors for autoimmune-mediated congenital heart block
(2017-11-24)
Placental transfer of maternal Ro/SSA and La/SSB autoantibodies during pregnancy is associated with conduction disturbances and inflammation in the developing fetal heart, termed autoimmune-mediated congenital heart block ...
K+ channels and the regulation of synaptic transmission
(2009-05-22)
Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to ...
SARS coronavirus : the role of accessory proteins and nitric oxide in the replication cycle
(2008-08-28)
Severe acute respiratory syndrome coronavirus (SARS-CoV) caused the first
pandemic of the 21st century. The etiological agent was identified as a
novel coronavirus. Until then, human coronaviruses (HCoVs) had only ...
Neuromodulation shapes interneuron communication in the mouse striatum
(2020-07-24)
A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of ...
Innate regulation of the adaptive immune system during autoimmunity
(2015-05-22)
Immune activation comprises multiple biological checkpoints to ensure proper
and regulated effector functions. Phagocytes such as macrophages, dendritic
cells and neutrophils have important functions during inflammation, ...
Lumbar fusion for chronic low-back pain in isthmic spondylolisthesis
(2008-11-21)
Manifestation of isthmic spondylolisthesis (IS), with a prevalence of 5% in the general population, varies from totally asymptomatic to severe disability. Although fusion has positive short-term effects, the long-term ...
How can older adults combat diabetes to achieve a longer and healthier life?
(2021-03-10)
Type 2 diabetes (hereafter, diabetes) and prediabetes are very common in older adults and constitute a great health concern for this population. The objective of this project is to investigate the impact of prediabetes and ...