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Functional analysis of genetic risk markers
(2017-11-02)
Regulatory variants are the main factors responsible for genetic predisposition to how e.g. humans react differently to the environment. Therefore, it is important to locate and measure their effects, which can result in ...
Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death
(2009-01-30)
In several neurodegenerative disorders, including Alzheimer disease (AD)
and Parkinson disease (PD), protein aggregation is accompanied by
mitochondrial dysfunction. An increasing number of proteins found in
mitochondria ...
The health economics of Duchenne muscular dystrophy
(2016-09-30)
Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease characterized by progressive muscle degeneration resulting in loss of independent ambulation, serious multisystem complications, and a mean life expectancy ...
Genetic determinants of postmenopausal breast and endometrial cancer
(2007-01-26)
Breast cancer is overall the most common cancer in women worldwide and
endometrial cancer is the most common gynaecological cancer in the
industrialized world. History of a first-degree relative with breast or
endometrial ...
Mitochondria in Alzheimer disease : regulatory mechanisms and cell death
(2012-08-24)
Synaptic loss is the major correlate for cognitive decline in Alzheimer disease (AD). Processes taking place in the synapses are highly energy demanding and needs strict regulation, which makes the mitochondria and ER ...