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Socioeconomic differences in alcohol habits, alcohol-related disorders and mortality
(2016-10-27)
The overall aim of this thesis is to enhance knowledge about stability and predictors of change in alcohol habits among different sociodemographic subgroups, and to assess the contribution of alcohol use to social differences ...
Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Role of estrogen receptor beta in epithelia lacking estrogen receptor alpha expression
(2008-04-18)
Estrogens influence the physiology of many organs by activation of the nuclear receptors ERalpha and ERbeta. The epithelium of ventral prostate, ovarian granulosa cells and lung, are ERalpha-negative but express high levels ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
In previous work from this laboratory, vital microscopy was successfully
used to study rnicrocirculatcry effects of hypercholesterolemia in a
rabbit model. Hypercholesterolemia caused a dramatic depression of the
blood ...
The association between hormonal/reproductive factors and the risk of developing rheumatoid arthritis
(2015-11-25)
Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to joint damage and bone destruction, with a complex interplay of genetic and environmental factors involved in its etiology. RA is more common among ...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for ...
Regulation of p53 and susceptibility to cell death in chemically-induced preneoplastic hepatocytes
(2003-11-20)
Induction of preneoplastic lesions, termed enzyme-altered foci (EAF), is considered to be an early step in the development of liver cancer. In view of the relatively homogenous properties of the majority of EAF, these ...
Chronic myeloid leukemia-clinical, experimental and health economic studies with special reference to imatinib treatment
(2013-02-01)
CML is a malignant disease that originates in the bone marrow stem cell, carrying the Philadelphia chromosome with the BCR-ABL fusion gene. This gene translates into an active tyrosine kinase, Bcr-Abl, affecting hematopoiesis, ...
Short and long term effects of bacterial gastrointestinal infection
(2008-05-09)
The objectives of this thesis were to increase our understanding of the
mortality and complications associated with bacterial gastrointestinal
infections, with focus on Salmonella and Campylobacter enteritis. The
effect ...