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NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway
(2016-11-11)
Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of ...
Pharmacokinetics and inner ear transport of cisplatin
(2015-02-25)
Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin
has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible
hearing loss. The ototoxic mechanisms of cisplatin ...
Prevention of liver cancer in chronic liver disease : an experimental study of sodium selenite and rat hepatocarcinogenesis
(2011-11-21)
Selenium treatment in supranutritional but subtoxic doses has previously been shown to inhibit cell proliferation in preneoplastic lesions in a rat liver carcinogenesis model. The mechanisms are not known, but thioredoxin ...
Molecular subclassification, stem cell markers and growth regulatory pathways in gliomas
(2015-05-11)
Glioblastoma is the most common and aggressive primary brain tumor in adults. Median
survival is no more than 15 months, even with combined treatment regimens. The lack of
accurate pre-clinical model systems has limited ...