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The effect of the tumor environment on the anti-tumor immune response
(2006-08-28)
Cancer immunotherapy is the process of stimulating the host's immune system to kill cancer cells, and it is being investigated as adjuvant therapy to traditional cancer treatments such as, surgery, radiation therapy and ...
Chemical transformation of the anticancer drug oxaliplatin
(2005-09-02)
Oxaliplatin is a new platinum based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin, both as palliative and adjuvant treatment of metastatic colorectal cancer. Various biotransformation products ...
HHV-8/KSHV association with tumor cells during development of Kaposi sarcoma
(2006-01-12)
Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion which usually presents as a cutaneous disease and progresses to extracutaneous, systemic spread usually in the gastrointestinal (GI) tract, ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Stem cell in-vitro strategies for the induction of sensory neurons for inner ear cell therapy
(2016-01-29)
The cochlea, a part of the auditory system, is a complex structure consisting of several
different types of cells including hair cells and spiral ganglion neurons. In mammals, the
regenerative potential of hair cells and ...
Analysis of HLA-A2 frequency as prognostic and/or risk factors in ovarian cancer patients
(2007-03-21)
Major histocompatibility complex antigens are mandatory for the immune response, and genetic imbalance may be linked to tumour escape. The HLA-A2 allele in Scandinavia has a high prevalence; it decreases with latitude and ...
Role of tartrate-resistant acid phosphatase in bone remodeling
(2019-11-27)
Tartrate-resistant acid phosphatase is a metalloenzyme that exists as two isoforms: the monomeric TRAP 5a and the proteolytically cleaved TRAP 5b, responsible for phosphatase activity, which is highly expressed in osteoclasts ...
Hormone-related factors and breast cancer : studies of risk and prognosis
(2006-08-18)
The main purpose of this thesis was to explore the influences of risk factors for breast cancer on breast cancer characteristics and survival.
We evaluated the associations between number and timing of births and ...