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The impact of genetics, environmental, and geographical factors on inter-individual and inter-ethnic differences in CYP2C9-catalysed drug metabolism
(2015-11-12)
Inter-individual and inter-ethnic variations in drug metabolism are creating an obstacle in
providing efficient and effective drug treatments especially for drugs with narrow therapeutic
windows. This thesis is contributes ...
Genetic epidemiological studies of the functional somatic syndromes : chronic widespread pain and chronic fatigue
(2007-02-02)
interview. Of 61,355 eligible twins, 44,897 individuals (73.2%) participated in the interview which screened, amongst others, for chronic widespread pain, chronic fatigue, irritable bowel syndrome, recurrent headache, major depression, and generalized...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits ...
Fibrinogen and susceptibility to myocardial infarction : role of gene-gene and gene-environment interactions
(2006-04-12)
Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in plasma at concentrations normally ranging between 2-4 g/L. The fibrinogen molecule consists of two sets of three non-identical ...