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Remodelling of the cellular environment in Epstein-Barr virus infection
(2015-02-13)
For successful infection viruses modify the host cell environment by transcriptional, posttranscriptional or post-translational regulation of cellular signaling pathways. In the work described in this thesis bioinformatics ...
Therapeutic response in human cancers : the dual role of STAT signalling
(2016-08-08)
STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects ...
Effects of acute alcohol exposure on glutamate neurotransmission in adolescents and adults : a preclinical study
(2013-09-13)
The age at which an individual first uses alcohol is a powerful predictor of alcohol dependence later in life. Brain development and maturation continues during adolescence until adulthood in humans. There are continuous ...
Implications of localization and transport regulation of postsynaptic membrane proteins for synaptic function and psychiatric disorders
(2013-11-21)
A fundamental means of regulating protein function in cells is through modulation of protein abundance at the sites of action via controlled transport processes. The complexity of neurons makes them especially reliant on ...
Synaptic transmission and synaptic plasticity in the mouse striatum
(2008-03-05)
The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit ...
Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development
(2007-02-16)
Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and ...