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Molecular studies of multiple endocrine neoplasia type 1 (MEN1)
(2000-08-25)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors of the parathyroids, the endocrine pancreas and anterior pituitary. The MEN1 locus has been previously ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Adolescent pregnancy and parenthood in Swaziland : quality of care, community support and health care service needs
(2006-12-25)
The aim of this thesis was to study - from different perspectives - adolescent pregnancy and parenthood in Swaziland. The specific objectives were to: i) explore maternity care practices and support for adolescent mothers ...
Telomerase reverse transcriptase (TERT) : promoter mutation and novel function in human cancer
(2014-05-21)
Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, an RNAdependent DNA polymerase responsible for telomere elongation. TERT is transcriptionally repressed in most normal human somatic cells ...
Vaccination in gastrointestinal cancer
(2014-01-31)
Advances in immunology have increased the possibility to develop therapeutic cancer vaccines (TCV), as a complementary approach to standard treatment. The goal of a successful cancer vaccine is to induce a potent long-lasting ...