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Health care in transition : threat or opportunity? Psychosocial work quality and health for staff and organization
(1997-09-23)
Impact of the psychosocial work environment on the health and well-being of health care personnel should be studied with a global view, including individual and organizational resources to cope with work conditions. Work ...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Wnt signaling in early brain development and disease
(2014-10-21)
Wnt/Planar Cell Polarity (PCP) signaling is involved in many cellular processes throughout the development of the embryo. These include control of proliferation, differentiation, migration and cell fate decisions. Deregulation ...
Small-molecule inhibitors of the receptor tyrosine kinases : promising tools for targeted cancer therapies
(2014-08-11)
Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a ...
Proteomics of invasiveness of human breast epithelial cells
(2012-01-25)
Mechanisms of malignant transformation and cancer invasion and factors controlling them in response to various stimuli remain elusive. We used proteomics and systems biology to explore these mechanisms in human breast ...
Immune mechanisms behind plaque vulnerability : experimental and clinical studies
(2010-10-21)
Physical disruption of atherosclerotic plaques causes many acute
thrombotic complications such as myocardial infarction and stroke. The
resistance of the atherosclerotic plaque to disruption depends in part on
the ...
Shoulder and upper extremity impairments, activity limitation and physiotherapeutic exercise in women with rheumatoid arthritis : a biopsychosocial approach
(2000-05-04)
The aim of this thesis was to evaluate both specially-designed and commonly used instruments for measuring impairments, activity limitation and health-related quality of life (overall Sickness Impact Profile (SIP)). The ...
Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome‐wide analyses
(2017-09-11)
Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling and ...
MRI quantification of multiple sclerosis pathology
(2021-02-02)
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease and a common cause of neurologic disability. MS pathology is characterized by demyelination, neuroaxonal loss and atrophy. ...
Effects of cognitive behavioural therapy targeting eating behaviour (CBT-TEB) : a novel obesity treatment
(2017-01-02)
Objective: The overall objective was to evaluate the outcome of the 10-week (20/30 h) CBTTEB treatment programme for persons with obesity. The evaluation took place in three studies.
Paper I (Study I): Method. One ...