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Nestin : filament formation and expression in myogenesis and muscle disorders
(1997-09-12)
Intermediate filaments (IF), together with microfilaments and microtubules, are the major components of the cytoskeleton of eukaryotic cells. In myogenic cells three IF proteins are expressed; desmin, vimentin and nestin. ...
Processing and presentation of exogenous antigen by dendritic cells
(2006-09-01)
Dendritic cells (DC) play a key role in the immune system. In this thesis, we have investigated and characterized pathways for the processing and presentation of exogenous OVA on MHC-I ("cross-presentation") and how these ...
Mesenchymal stromal/stem cells : expansion, engraftment and immune modulation
(2009-04-07)
Due to their production of hematopoietic growth factors and their
immunomodulatory capacity, bone marrow-derived mesenchymal stromal/stem
cells (MSC), are a promising tool in the procedure of hematopoietic stem
cell ...
Endocrine and paracrine factors related to pregnancy and infertility
(2019-05-24)
Unexplained infertility, one of the common gynecological disorders, affecting 10 to 15 % of women worldwide. Recurrent pregnancy loss affects approximately 1 to 3 % of pregnant women with an unknown etiology in 50 % of ...
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(2008-01-04)
The SS18 and SSX genes were initially identified based on their
reoccurrence as fusion partners in synovial sarcoma. As a result of the
specific chromosomal translocation t(X:18), the SS18 gene from chromosome
18 becomes ...
Dietary inorganic nitrate : role in exercise physiology, cardiovascular and metabolic regulation
(2011-05-24)
Nitric oxide (NO) is a ubiquitous signaling molecule with a vast number of tasks in the body, including regulation of cardiovascular and metabolic function. A decreased bioavailability of NO is a central event in disorders ...
Side-chain oxidized oxysterols as metabolic regulators in vivo
(2017-02-28)
Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half- life and their ability to pass lipophilic membranes easily, and they are considered as important intermediates in the excretion ...
Hereditary factors in endometrial cancer
(2015-02-03)
Endometrial carcinoma (EC) is the most common gynecological malignancy in Sweden and accounts for about 6 % of all female malignancies. The risk of EC increases with age and the majority of cases are diagnosed between age ...
Mild traumatic brain injury : clinical course and prognostic factors for postconcussional disorder
(2006-12-29)
Background: Mild traumatic brain injury (MTBI) is frequent and sometimes leads to
persistent disability. It remains a matter of controversy as to what
impact the different main determinants - brain injury factors ...
Equity and equality : case detection of tuberculosis among women and men in Vietnam
(2003-05-02)
Background: The global Tuberculosis (TB) control strategy recommended by the WHO, DOTS, is based on identification of sputum smear-positive pulmonary TB cases by self-referral to health services. The target set by the WHO ...