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Interferons in immunity to chlamydia pneumoniae
(2004-02-12)
The cytokine IFN-gamma is the architect behind an amazing immunological
program of host resistance to intracellular bacterial and protozoan
infections. IFN-gamma activates macrophages, making them into
inhospitable ...
Analyses of protein evolution, function, and architecture
(2010-01-25)
Proteins can evolve over time in many different ways. An ancestral protein sequence inherited in different species will gradually undergo changes in primary sequence and sometimes in domain architecture. Some of these ...
Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease
(2006-03-31)
Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The ...
Molecular dissection of Bruton’s tyrosine kinase signaling in hematopoietic cells using RNAi
(2007-09-19)
RNA mediated gene silencing, RNA interference (RNAi), has recently been
identified in mammalians. This thesis describes the utilization and
development of RNAi based tools for signal transduction research. The
effects ...