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Immunogenetic markers in immune mediated diseases
(2003-11-21)
The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile ...
Epidermal stem cells in physiological tissue regeneration, wound healing and cancer
(2016-01-29)
The mammalian skin is a versatile organ that protects from external harm, regulates the body temperature, and provides the touch sensation. Its epithelium, the epidermis, forms several highly regenerative structures as the ...
Neural growth : with special emphasis on adult neurogenesis and the effect of antiepileptic drugs
(2008-05-23)
Neurons were for a long time thought to not renew themselves. In the
1960ies the phenomenon of neurogenesis was discovered, but it was not
until 1998 that neurogenesis was demonstrated in humans. In this thesis
neurogenesis ...
Expression of inflammatory and insulin signaling genes in acute and chronic stress
(2010-05-17)
The acute surgical stress response induces a short-term inflammatory and insulin resistant condition, commonly producing hyperglycemia, which is strongly associated to morbidity and mortality in postsurgical patients. The ...
Ultraviolet light, autoimmune disorders and the etiology of malignant lymphomas
(2005-05-13)
Malignant lymphomas constitute a clinically and morphologically diverse group of malignancies that may also differ etiologically. The incidence of the most common non-Hodgkin lymphomas (NHL) has increased dramatically ...
Genetics and biomarkers of frailty : towards individualized management of the frailty syndrome
(2023-10-09)
Frailty is an age-related, dynamic state of multisystem physiological decline and is a
strong predictor of disability and mortality. To move towards an individualized management
of frailty, a better understanding of its ...