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PPAR delta : its role in cholesterol metabolism
(2003-08-08)
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that regulate several biological processes, many of which are crucial for energy homeostasis. Three different isotypes have ...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. ...
The interplay between mitochondria-endoplasmic reticulum contacts and Alzheimer’s disease
(2019-03-22)
Even though Alzheimer’s disease (AD) was first described more than 100 years ago, we still have no treatment preventing the ongoing neurodegenerative process. Two major pathological hallmarks have been connected to AD: ...
HealthyMoms : a smartphone application to promote healthy weight gain, diet and physical activity during pregnancy : a randomized controlled trial
(2022-06-01)
Background: The prevalence of overweight and obesity is a major public health concern, also among pregnant women. Alarmingly, around half of pregnant women in high income countries exceed the recommendations for an optimal ...