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Endothelin and endothelin receptors in human pregnancy and delivery
(1996-09-06)
Background: Endothelin-1 (ET-1) is a 21-amino acid peptide, first described by Yanagisawa et al in 1988. It is one of the most potent constrictors of smooth muscle cells identified to date. The facts that ET bears no ...
Inference of systems-level behaviors in the immune system from single-cell data
(2020-03-27)
Understanding the systems-level behaviours of the immune system requires profiling many parameters of its constituents as well as identifying environmental factors influencing the time evolution of immune response. Recent ...
Role of c-di-GMP signalling in bacterial-host interactions
(2010-09-09)
Bacteria have various ways to sense environmental signals and to adapt their behavior and physiology through different signaling systems. Secondary messenger signaling, amplified by enzymatic activity, rapidly transmits a ...
Genetic and molecular determinants in inflammatory bowel disease
(2006-11-21)
Inflammatory Bowel Disease, IBD, are polygenic disorders that present itself to the clinician as a sum of interacting events arising from multiple factors of genetic, immunological and environmental origin, resulting in a ...
Characterization of Escherichia coli colonizing the gastrointestinal tract and urinary tract catheters
(2008-11-17)
Commensal and pathogenic bacteria express biofilm behaviour which is thought to alter bacteria-host interactions and contribute to colonization and persistence. In the current thesis, the epidemiology of biofilm formation ...